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Trade Name	Drug Name	Approved	Patent Expires	Indication
Vonjo	Pacritinib	2022-02-28	2028-2030	Primary myelofibrosis

Clinical Trials

Therapeutic Areas:

All

Classification:

All

Approval:

All

Status:

All

Phases:

All

Drug Name

Phase 1

Phase 2

Phase 3

Phase 4

Indication

healthy volunteers/patients

,

drug interactions

,

leukemia myeloid chronic atypical bcr-abl negative

,

non-small-cell lung carcinoma

,

,

renal insufficiency

,

t-cell lymphoma peripheral

,

t-cell lymphoma cutaneous

,

b-cell lymphoma

,

,

hepatic insufficiency

,

,

,

myelodysplastic syndromes

,

myeloproliferative disorders

,

,

myeloid leukemia acute

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia juvenile

,

,

,

myeloid leukemia

,

lymphoproliferative disorders

,

mantle-cell lymphoma

,

myelodysplastic-myeloproliferative diseases

,

bcr-abl positive chronic myelogenous leukemia

,

myelomonocytic leukemia acute

,

lymphoid leukemia

,

graft vs host disease

,

b-cell chronic lymphocytic leukemia

,

t-cell lymphoma

,

waldenstrom macroglobulinemia

,

hodgkin disease

,

,

,

precursor cell lymphoblastic leukemia-lymphoma

,

prostatic neoplasms

,

breast neoplasms

,

,

colorectal neoplasms

,

bronchiolitis obliterans syndrome

,

,

castleman disease

,

,

,

adenocarcinoma of lung

,

primary myelofibrosis

,

polycythemia vera

,

essential thrombocythemia

,

,

,

thrombocytopenia

,

Aglatimagene besadenovec

,

diabetes mellitus

,

positron emission tomography computed tomography

,

sedentary behavior

,

,

intestinal neoplasms

,

,

pleural effusion

,

nasopharyngeal carcinoma

,

nasopharyngeal neoplasms

,

male breast neoplasms

,

b-cell chronic lymphocytic leukemia

,

,

preoperative exercise

,

hodgkin disease

,

hyperparathyroidism

,

digestive system neoplasms

,

invasive hydatidiform mole

,

malignant pleural effusion

,

drug interactions

,

,

,

mantle-cell lymphoma

,

,

,

thymus neoplasms

,

myeloid leukemia

,

secondary hyperparathyroidism

,

,

unknown primary neoplasms

,

lobular carcinoma

,

cutaneous malignant melanoma

,

prolymphocytic leukemia t-cell

,

prolymphocytic leukemia

,

myeloproliferative disorders

,

myelodysplastic-myeloproliferative diseases

,

adrenocortical carcinoma

,

adenoviridae infections

,

,

pancreas transplantation

,

graft pancreatitis

,

b-cell lymphoma marginal zone

,

burkitt lymphoma

,

lymphoid leukemia

,

neoplasms by histologic type

,

acinar cell carcinoma

,

mucoepidermoid carcinoma

,

mucoepidermoid tumor

,

pathologic neovascularization

,

,

coxsackievirus infections

,

pharyngeal neoplasms

,

inflammatory breast neoplasms

,

,

,

basal cell carcinoma

,

basal cell neoplasms

,

follicular lymphoma

,

adjuvant radiotherapy

,

pharmacokinetics

,

pharmacological phenomena

,

local neoplasm recurrence

,

esophageal squamous cell carcinoma

,

,

glucose intolerance

,

hyperlipidemias

,

emission-computed tomography single-photon

,

pancreatic neoplasms

,

renal cell carcinoma

,

kidney neoplasms

,

circulating neoplastic cells

,

,

stomach neoplasms

,

esophageal neoplasms

,

,

small cell lung carcinoma

,

colonic neoplasms

,

triple negative breast neoplasms

,

,

rectal neoplasms

,

neuroendocrine carcinoma

,

,

brain neoplasms

,

squamous cell carcinoma of head and neck

,

,

transitional cell carcinoma

,

hereditary breast and ovarian cancer syndrome

,

small cell carcinoma

,

squamous cell carcinoma

,

,

,

,

cognitive dysfunction

,

thyroid neoplasms

,

hematologic neoplasms

,

,

,

cholangiocarcinoma

,

salivary gland neoplasms

,

testicular neoplasms

,

non-hodgkin lymphoma

,

thromboembolism

,

,

squamous cell neoplasms

,

,

,

adenoid cystic carcinoma

,

,

,

,

pancreatic ductal carcinoma

,

biliary tract neoplasms

,

vulvar neoplasms

,

,

tobacco use disorder

,

neoadjuvant therapy

,

myelodysplastic syndromes

,

,

,

dna repair-deficiency disorders

,

intraductal carcinoma noninfiltrating

,

central nervous system neoplasms

,

malignant mesothelioma

,

,

,

uterine neoplasms

,

atrial fibrillation

,

peripheral nervous system diseases

,

urethral neoplasms

,

nervous system neoplasms

,

large b-cell lymphoma diffuse

,

b-cell lymphoma

,

dna mismatch repair

,

,

,

,

,

ductal carcinoma

,

urological manifestations

,

myeloid leukemia acute

,

microsatellite instability

,

thyroid diseases

,

clear cell adenocarcinoma

,

adenomyoepithelioma

,

uveal neoplasms

,

,

,

premature birth

,

,

,

,

smoldering multiple myeloma

,

paraproteinemias

,

monoclonal gammopathy of undetermined significance

,

bile duct neoplasms

,

gallbladder neoplasms

,

,

,

lymphadenopathy

,

,

lacrimal apparatus diseases

,

disease-free survival

,

,

hormone-dependent neoplasms

,

mycobacterium infections

,

palliative care

,

,

abdominal neoplasms

,

myelomonocytic leukemia chronic

,

systemic mastocytosis

,

myelomonocytic leukemia juvenile

,

hypereosinophilic syndrome

,

,

dermatofibrosarcoma

,

t-cell lymphoma

,

,

,

,

neurotoxicity syndromes

,

vitamin d deficiency

,

stress fractures

,

adenocarcinoma in situ

,

genetic polymorphism

,

risk reduction behavior

,

,

traumatic stress disorders

,

,

,

glandular and epithelial neoplasms

,

,

,

,

residual neoplasm

,

solitary fibrous tumors

,

,

hemangiopericytoma

,

human influenza

,

liver transplantation

,

gastric outlet obstruction

,

large cell carcinoma

,

combination drug therapy

,

,

adenomatous polyposis coli

,

craniopharyngioma

,

,

wnt signaling pathway

,

,

adenosquamous carcinoma

,

islet cell carcinoma

,

,

optical imaging

,

thrombocytopenia

,

,

,

,

,

,

colorectal neoplasms

,

ovarian neoplasms

,

head and neck neoplasms

,

liver neoplasms

,

urologic neoplasms

,

uterine cervical neoplasms

,

,

endometrial neoplasms

,

hepatocellular carcinoma

,

,

disease progression

,

physiological sexual dysfunction

,

,

,

healthy volunteers/patients

,

stress urinary incontinence

,

ovarian epithelial carcinoma

,

,

radiation effects

,

magnetic resonance imaging

,

insulin resistance

,

prostatic intraepithelial neoplasia

,

,

,

female genital neoplasms

,

precancerous conditions

,

positron-emission tomography

,

gastrointestinal neoplasms

,

carcinoma in situ

,

communicable diseases

,

pelvic neoplasms

,

,

germ cell and embryonal neoplasms

,

,

fallopian tube neoplasms

,

gastrointestinal diseases

,

urge urinary incontinence

,

,

urination disorders

,

,

metabolic bone diseases

,

postoperative complications

,

diagnostic imaging

,

,

,

venous thrombosis

,

premature ejaculation

,

,

chronic disease

,

vaginal neoplasms

,

bacterial infections

,

penile erection

,

,

type 2 diabetes mellitus

,

bone resorption

,

peritoneal neoplasms

,

,

alopecia areata

,

,

post-traumatic stress disorders

,

,

epidural analgesia

,

,

androgen-insensitivity syndrome

,

,

,

hepatic veno-occlusive disease

,

,

breakthrough pain

,

minimally invasive surgical procedures

,

thoracic surgical procedures

,

urinary catheterization

,

,

polycystic ovary syndrome

,

male infertility

,

vision disorders

,

directly observed therapy

,

passive cutaneous anaphylaxis

,

prostatic neoplasms

,

prostatic hyperplasia

,

castration-resistant prostatic neoplasms

,

,

,

,

breast neoplasms

,

,

,

neoplasm metastasis

,

lower urinary tract symptoms

,

urinary bladder neoplasms

,

hypersensitivity

,

erectile dysfunction

,

urinary incontinence

,

,

non-small-cell lung carcinoma

,

,

prostatic diseases

,

,

,

,

,

urinary retention

,

urogenital neoplasms

,

transurethral resection of prostate

,

overactive urinary bladder

,

,

multiple myeloma

,

bone marrow diseases

,

lymphatic metastasis

,

,

second primary neoplasms

,

,

cardiovascular diseases

,

,

urinary bladder neck obstruction

,

metabolic syndrome

,

plasma cell neoplasms

,

urologic diseases

,

male genital neoplasms

,

neuroendocrine tumors

,

,

male genital diseases

,

genital diseases

,

,

,

,

,

anxiety disorders

,

urinary tract infections

,

male urogenital diseases

,

urogenital diseases

,

,

neoplasms by site

,

,

drug-related side effects and adverse reactions

,

postoperative pain

,

,

underactive urinary bladder

,

,

coronary artery disease

,

myocardial ischemia

,

wounds and injuries

,

,

neurogenic urinary bladder

,

nephrolithiasis

,

intraoperative complications

,

renal insufficiency

,

,

peripheral nerve injuries

,

retinal diseases

,

,

ureteral obstruction

,

pneumoperitoneum

,

autonomic nervous system diseases

,

intravenous administration

,

,

pituitary neoplasms

,

pituitary acth hypersecretion

,

pituitary diseases

,

acth-secreting pituitary adenoma

,

dumping syndrome

,

,

,

airway obstruction

,

osteochondrodysplasias

,

,

,

,

choroid diseases

,

blood coagulation disorders

,

hemostatic disorders

,

nerve regeneration

,

primary dysautonomias

,

,

genetic predisposition to disease

,

,

,

ejaculatory dysfunction

,

penile neoplasms

,

venous thromboembolism

,

spinal anesthesia

,

,

sleep initiation and maintenance disorders

,

urethral obstruction

,

disease susceptibility

,

,

ureteral neoplasms

,

health behavior

,

,

multiparametric magnetic resonance imaging

,

patient satisfaction

,

,

ultrasonography

,

pelvic floor disorders

,

,

intestinal diseases

,

,

,

,

,

,

acute kidney injury

,

digital rectal examination

,

psychological distress

,

,

radiation injuries

,

,

,

,

,

depressive disorder

,

,

,

coronary disease

,

,

,

cardiac arrhythmias

,

heart disease risk factors

,

,

,

resistance training

,

,

mullerian mixed tumor

,

body composition

,

,

psychological sexual dysfunctions

,

soft tissue neoplasms

,

fecal incontinence

,

decision support techniques

,

kidney diseases

,

,

psychological stress

,

,

,

spinal neoplasms

,

erythema multiforme

,

therapeutic embolization

,

myocardial infarction

,

cross infection

,

,

,

,

local anesthesia

,

urinary bladder diseases

,

spinal cord injuries

,

interstitial cystitis

,

,

exercise therapy

,

pulmonary embolism

,

hereditary nonpolyposis colorectal neoplasms

,

,

trigeminal neuralgia

,

,

patient participation

,

patient preference

,

urinary calculi

,

high-intensity focused ultrasound ablation

,

metabolic diseases

,

parathyroid neoplasms

,

ureteral calculi

,

ureterolithiasis

,

,

,

postoperative hemorrhage

,

thoracic neoplasms

,

shared decision making

,

,

,

pain management

,

patient acceptance of health care

,

clostridium botulinum type a

,

disease resistance

,

surgical blood loss

,

pharmacogenomic testing

,

,

prostheses and implants

,

,

,

,

,

carcinoid tumor

,

inguinal hernia

,

,

,

chronic kidney disease-mineral and bone disorder

,

,

,

supraventricular tachycardia

,

stomatognathic diseases

,

endocrine system diseases

,

autoimmune diseases

,

neurocognitive disorders

,

intravenous anesthesia

,

,

intermittent fasting

,

paraneoplastic syndromes

,

neurodegenerative diseases

,

interdisciplinary communication

,

inflammatory bowel diseases

,

,

embolism and thrombosis

,

rectal diseases

,

,

body weight changes

,

,

chronic renal insufficiency

,

polycystic kidney diseases

,

,

systemic scleroderma

,

psoriatic arthritis

,

,

atopic dermatitis

,

,

ulcerative colitis

,

parkinson disease

,

ankylosing spondylitis

,

multiple sclerosis

,

,

chronic obstructive pulmonary disease

,

,

,

lupus nephritis

,

papillomaviridae

,

glucosephosphate dehydrogenase deficiency

,

sickle cell anemia

,

,

acquired immunodeficiency syndrome

,

,

cystic fibrosis

,

thrombocytopenic purpura idiopathic

,

,

,

duchenne muscular dystrophy

,

sjogren's syndrome

,

obstructive lung diseases

,

systemic lupus erythematosus

,

beta-thalassemia

,

,

,

hereditary hemorrhagic telangiectasia

,

spondylarthritis

,

sickle cell trait

,

,

,

,

polyneuropathies

,

thrombotic thrombocytopenic purpura

,

huntington disease

,

diffuse scleroderma

,

muscular atrophy

,

spinal muscular atrophy

,

,

,

chronic inflammatory demyelinating polyradiculoneuropathy

,

thrombocytopenic purpura

,

,

,

facioscapulohumeral muscular dystrophy

,

muscular dystrophies

,

,

,

,

myotonic dystrophy

,

,

bipolar disorder

,

attention deficit disorder with hyperactivity

,

chronic kidney failure

,

orthostatic hypotension

,

diabetes insipidus

,

,

pudendal neuralgia

,

,

,

ocular hypertension

,

spinal cord neoplasms

,

,

pathologic constriction

,

urethral stricture

,

,

rectovaginal fistula

,

atherosclerotic plaque

,

kidney transplantation

,

,

geriatric psychiatry

,

personal satisfaction

,

disease attributes

,

artificial intelligence

,

cross-sectional studies

,

hypercholesterolemia

,

ultrasonic therapy

,

,

,

radiofrequency ablation

,

solid-state lasers

,

,

spinal dysraphism

,

bladder exstrophy

,

urinary bladder calculi

,

,

neoplasm staging

,

alzheimer disease

,

epidemiologic studies

,

penile implantation

,

high-intensity focused ultrasound transrectal

,

innate immunity

,

,

somatoform disorders

,

lymphatic diseases

,

,

compartment syndromes

,

interventional ultrasonography

,

prospective studies

,

image-guided biopsy

,

,

genetic markers

,

robotic surgical procedures

,

psychology biofeedback

,

amyotrophic lateral sclerosis

,

motor neuron disease

,

diagnostic techniques and procedures

,

,

,

uterine artery embolization

,

arteriovenous malformations

,

neoplasm micrometastasis

,

,

mitochondrial diseases

,

,

,

,

pleural neoplasms

,

pelvic organ prolapse

,

,

von hippel-lindau disease

,

hereditary neoplastic syndromes

,

opioid-related disorders

,

body temperature changes

,

,

,

papillary thyroid cancer

,

medullary carcinoma

,

catheter ablation

,

non-alcoholic fatty liver disease

,

vasovagal syncope

,

,

margins of excision

,

,

enhanced recovery after surgery

,

post-acute covid-19 syndrome

,

sleep wake disorders

,

adrenal rest tumor

,

respiratory aspiration

,

artificial respiration

,

positive-pressure respiration

,

treatment adherence and compliance

,

physician-patient relations

,

,

transfusion reaction

,

,

,

immune system diseases

,

memory disorders

,

,

digestive system diseases

,

arterial occlusive diseases

,

,

traumatic brain injuries

,

,

,

rhabdomyosarcoma

,

,

schistosoma haematobium

,

,

,

,

mouth neoplasms

,

professional-patient relations

,

,

genetic testing

,

vascular access devices

,

hiv seropositivity

,

,

image-guided radiotherapy

,

acupuncture therapy

,

,

pain measurement

,

oligodendroglioma

,

,

mental disorders

,

,

randomized controlled trials as topic

,

tertiary lymphoid structures

,

genetic risk score

,

,

,

motor skills disorders

,

cardiometabolic risk factors

,

,

urologic surgical procedures

,

major depressive disorder

,

treatment outcome

,

,

nervous system diseases

,

epidural anesthesia

,

,

elective surgical procedures

,

financial stress

,

acupuncture analgesia

,

,

general anesthesia

,

obstructive sleep apnea

,

sleep apnea syndromes

,

attention deficit disorder with hyperactivity

,

,

impulsive behavior

non-hodgkin lymphoma

,

,

healthy volunteers/patients

,

hepatic insufficiency

,

esophageal neoplasms

,

,

small cell lung carcinoma

,

pancreatic ductal carcinoma

,

multiple myeloma

,

plasma cell neoplasms

,

bronchiolitis obliterans syndrome

,

congenital abnormalities

,

chromosome aberrations

,

brain stem neoplasms

,

chronic hepatitis c

,

chronic hepatitis

,

,

,

medulloblastoma

,

,

,

choroid plexus neoplasms

,

primitive neuroectodermal tumors

,

,

,

neuroepithelial neoplasms

,

ganglioneuroblastoma

,

neuroectodermal tumors

,

phenylketonurias

,

precursor t-cell lymphoblastic leukemia-lymphoma

,

nasopharyngeal carcinoma

,

ureteral neoplasms

,

pelvic neoplasms

,

adenoid cystic carcinoma

,

metabolic syndrome

,

follicular lymphoma

,

,

pancreatic neoplasms

,

prostatic neoplasms

,

kidney neoplasms

,

,

,

head and neck neoplasms

,

neurofibromatoses

,

,

liver neoplasms

,

,

neurofibromatosis 1

,

,

plexiform neurofibroma

,

endometrial neoplasms

,

systemic scleroderma

,

diffuse scleroderma

,

b-cell chronic lymphocytic leukemia

,

neuroendocrine carcinoma

,

central nervous system neoplasms

,

ovarian neoplasms

,

t-cell lymphoma

,

mantle-cell lymphoma

,

urinary bladder neoplasms

,

squamous cell carcinoma

,

uterine cervical neoplasms

,

myelodysplastic syndromes

,

non-hodgkin lymphoma

,

nervous system neoplasms

,

hypereosinophilic syndrome

,

systemic mastocytosis

,

,

uveal neoplasms

,

,

squamous cell carcinoma of head and neck

,

transitional cell carcinoma

,

castration-resistant prostatic neoplasms

,

primary myelofibrosis

,

,

graft vs host disease

,

adenocarcinoma of lung

,

diffuse intrinsic pontine glioma

,

disease progression

,

oligodendroglioma

,

neurofibromatosis 2

,

acoustic neuroma

,

,

hodgkin disease

,

islet cell carcinoma

,

hematologic diseases

,

myeloid leukemia accelerated phase

,

,

mast-cell leukemia

,

,

germ cell and embryonal neoplasms

,

,

anaplastic thyroid carcinoma

,

t-cell lymphoma peripheral

,

waldenstrom macroglobulinemia

,

malignant mesothelioma

,

,

,

cholangiocarcinoma

,

chronic disease

,

large-cell lymphoma anaplastic

,

plasma cell granuloma

,

,

,

,

,

gouty arthritis

,

endocrine gland neoplasms

,

,

urogenital neoplasms

,

male genital diseases

,

prostatic diseases

,

abdominal neoplasms

,

male genital neoplasms

,

genital diseases

,

sjogren's syndrome

,

retinitis pigmentosa

,

,

,

giant cell tumors

,

pigmented villonodular synovitis

,

giant cell tumor of tendon sheath

,

choroidal neovascularization

,

pathologic neovascularization

,

hemangioblastoma

,

von hippel-lindau disease

,

inflammatory breast neoplasms

,

invasive hydatidiform mole

,

multidrug-resistant tuberculosis

,

local neoplasm recurrence

,

t-cell lymphoma cutaneous

,

peutz-jeghers syndrome

,

acute coronary syndrome

,

st elevation myocardial infarction

,

type 1 diabetes mellitus

,

,

intestinal neoplasms

,

testicular neoplasms

,

,

brain stem infarctions

,

,

sturge-weber syndrome

,

klippel-trenaunay-weber syndrome

,

neurofibrosarcoma

,

nerve sheath neoplasms

,

carcinoma in situ

,

breast diseases

,

multiple hamartoma syndrome

,

,

urologic neoplasms

,

fallopian tube neoplasms

,

t-cell leukemia

,

localized scleroderma

,

myelomonocytic leukemia chronic

,

myelomonocytic leukemia acute

,

myelomonocytic leukemia juvenile

,

,

,

ovarian epithelial carcinoma

,

sickle cell anemia

,

streptococcus agalactiae

,

clear cell adenocarcinoma

,

adenomyoepithelioma

,

colorectal neoplasms

,

myeloid leukemia acute

,

,

,

neoplasm metastasis

,

,

chronic urticaria

,

,

brain neoplasms

,

hepatocellular carcinoma

,

,

large b-cell lymphoma diffuse

,

thyroid neoplasms

,

thyroid diseases

,

,

b-cell lymphoma

,

,

hematologic neoplasms

,

triple negative breast neoplasms

,

,

colonic neoplasms

,

,

stomach neoplasms

,

carcinoid tumor

,

pulmonary arterial hypertension

,

familial primary pulmonary hypertension

,

,

gastrointestinal neoplasms

,

rectal neoplasms

,

,

meningococcal meningitis

,

meningococcal infections

,

,

rheumatoid arthritis

,

multiple sclerosis

,

relapsing-remitting multiple sclerosis

,

organ transplantation

,

graft rejection

,

digestive system neoplasms

,

cutaneous malignant melanoma

,

,

lymphangioleiomyomatosis

,

lupus nephritis

,

,

hypersensitivity

,

peanut hypersensitivity

,

chronic inducible urticaria

,

hidradenitis suppurativa

,

,

interstitial lung diseases

,

,

lung transplantation

,

malignant carcinoid syndrome

,

serotonin syndrome

,

food hypersensitivity

,

psoriatic arthritis

,

,

muscular atrophy

,

spinal muscular atrophy

,

,

,

,

idiopathic pulmonary fibrosis

,

pulmonary fibrosis

,

,

infectious skin diseases

,

bacterial skin diseases

,

,

myasthenia gravis

,

muscle weakness

,

neoplasms by histologic type

,

neoplasms by site

,

,

myeloid leukemia

,

,

bcr-abl positive chronic myelogenous leukemia

,

breast neoplasms

,

,

,

non-small-cell lung carcinoma

,

renal cell carcinoma

,

,

kidney transplantation

,

philadelphia chromosome

,

lymphoid leukemia

,

neuroendocrine tumors

,

gastrointestinal stromal tumors

,

precursor cell lymphoblastic leukemia-lymphoma

,

,

myeloid leukemia chronic-phase

,

liver transplantation

,

renal insufficiency

,

tuberous sclerosis

,

chronic kidney failure

,

heart transplantation

,

kidney diseases

,

islet cell adenoma

,

,

,

macular degeneration

,

,

,

,

autosomal dominant polycystic kidney

,

communicable diseases

,

polycystic kidney diseases

,

,

diabetes mellitus

,

tick-borne encephalitis

,

,

immunosuppression therapy

,

cytomegalovirus infections

,

,

large cell carcinoma

,

vascular diseases

,

,

,

vision disorders

,

,

type 2 diabetes mellitus

,

cross-sectional studies

,

,

polyomavirus infections

,

cryopyrin-associated periodic syndromes

,

polycythemia vera

,

,

,

systolic heart failure

,

myocardial infarction

,

,

,

inferior wall myocardial infarction

renal insufficiency

,

primary myelofibrosis

,

hodgkin disease

,

large b-cell lymphoma diffuse

,

follicular lymphoma

,

b-cell lymphoma

,

non-hodgkin lymphoma

Polyglycolic acid

,

healthy volunteers/patients

,

,

myeloid leukemia acute

,

myeloid leukemia

,

myelodysplastic syndromes

,

,

,

neoplasm metastasis

,

pancreatic neoplasms

,

,

non-small-cell lung carcinoma

,

,

multiple myeloma

,

plasma cell neoplasms

Microcrystalline cellulose

zika virus infection

,

,

,

borrelia infections

,

ventilator-associated pneumonia

,

clostridium infections

,

clostridioides difficile

,

,

chikungunya fever

,

,

japanese encephalitis

,

pseudomonas infections

,

chikungunya virus

healthy volunteers/patients

1

2

>

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